Matchday 16 is packed with plenty of must-see fixtures, with City, Chelsea, Liverpool, and more all in action this weekend.

Last round saw some major changes in the Premier League table, as Chelsea slipped from first to third after a surprise loss to a high-flying West Ham. That now has seen reigning champs Manchester City assume pole position, with Liverpool hot on their heels.

Will we see more changes in the race for the Premier League title by the time matchday 16 finishes?

Here's all you need to know ahead of matchday 16.

Premier League standings heading into matchday 16

Here's how the top five looks heading into matchday 16

Premier League games you won't want to miss on matchday 16

Manchester City vs Wolves: Reigning champs City have been in excellent form, and will come into their tie having won their last five Premier League games. While Pep Guardiola's side slipped up during their last UCL group stage game, falling 2-1 to RB Leipzig, it was a moot point as they still qualified for the round of 16 as group runners-up, while Leipzig ended up in third and will be featuring in the Europa League. Given that Liverpool and Chelsea are lurking just behind, City will not be taking this clash lightly, despite the fact that Wolves have failed to win their last three games.

Arsenal vs Southampton: Arsenal fans were celebrating a while back as the Gunners, after a horrible start, had started to show some signs of improvement. However, they've been brought back down to earth as Mikel Arteta's side now come into their upcoming game with Southampton having lost two on the trot. Currently in seventh spot, the London side will obviously look to rebound here, especially as their opponents sit in 16th with just one win from their last five games.

Chelsea vs Leeds United: Last weekend saw Chelsea, who were then on top of the Premier League table suffer their second loss of the season. It indeed was a real thriller as the Blues traveled to face fellow London side West Ham, but at the end of 90 minutes, it was the Hammers and their home support who were celebrating. The Blues, still clearly rattled following their loss ended up shockingly drawing Russian outfit Zenit, which now means that Juventus were able to sneak into top spot and avoid a tougher draw in the round of 16. Will Thomas Tuchel's side be able to get back to winning ways when they host a Leeds United side who've won just one of their last five?

Liverpool vs Aston Villa: Liverpool, along with Chelsea, could potentially finish matchday 16 on top of the table. Should City fail to beat Wolves, and Liverpool, who play a few hours later, get the job done against Aston Villa, Jurgen Klopp's men will be the new league leaders. This game will be especially interesting, as Aston Villa are now under the leadership of none other than Reds icon Steven Gerrard. However, any sentimental feelings will have to be put on the back burner when the legendary midfielder arrives at his former home ground, as both teams will naturally be going for a much needed win.

Norwich vs Manchester United: Manchester United will come into this contest having won two on the spin, and given that Norwich are rooted to the bottom of the table, with just two wins so far all season, this match, on paper at least, should present a great chance for the Red Devils to make up some of their lost ground. Despite dropping two points in a frustrating draw with a very stubbornly defensive Young Boys side, Manchester United are nonetheless through to the round of 16 as group winners, and the Red Devils could technically start put pressure on fourth-placed West Ham if they can beat Norwich and the Hammers fail to win their game.

Brighton vs Tottenham: Having won three league games on the spin following Antonio Conte's arrival, Spurs were hoping to make it four consecutive victories and continue working their way up the table when they traveled to face Brighton this weekend. However, due to an outbreak of the latest installment of COVID-19 in their ranks, the visitors have now seen their match, which was scheduled for Sunday, called off and postponed.

Team news for matchday 16

Here's who's out or in doubt for matchday 16

*All info as of 10 December 2021

Manchester City: Ferran Torres (Ankle/Foot Injury), Benjamin Mendy (Suspended by Club); Doubtful - Gabriel de Jesus; Aymeric Laporte, Phil Foden, Nathan Ake

Liverpool: Roberto Firmino (Thigh Injury), Nathaniel Phillips (Head/Facial Injury), Curtis Jones (Head/Facial Injury); Doubtful - Diogo Jota

Chelsea: Ben Chilwell (Knee Injury), N'Golo Kante (Knee Injury),  Trevoh Chalobah (Thigh Injury), Mateo Kovacic (COVID-19)

West Ham: Angelo Ogbonna (Knee Injury), Ryan Fredericks (Groin/Hip Injury), Kurt Zouma (Thigh Injury), Benjamin Johnson (Thigh Injury); Doubtful - Aaron Cresswell (Lower Back Injury)

Tottenham: Son Heung-Min (COVID-19), Bryan Gil (COVID-19), Lucas (COVID-19), Emerson (COVID-19), Dane Scatlett (COVID-19), Oliver Skipp (COVID-19), Sergio Reguilon (Unspecified Injury), Cristiano Romero (Thigh Injury); Doubtful - Giovani Lo Celso (Knee Injury)

Manchester United: Raphael Varane (Thigh Injury), Edinson Cavani (Knock), Anthony Martial (Knee Injury), Paul Pogba (Thigh Injury); Doubtful - Aaron Wan-Bissaka, Nemanja Matic

Arsenal: Sead Kolasinac (Ankle/Foot Injury), Bernd Leno (Groin/Hip Injury), Emile Smith Rowe (Groin/Hip Injury)

Premier League matchday 16 fixtures